CAPSULE OF IMPROVED RELEASE CONTAINING FLUCONAZOLE

The object of the invention is to provide fluconazole containing capsules with improved active ingredient release. The in vitro dissolution as well as in vivo absorption of the fluconazole capsules according to the invention is faster and more consistent than those of commercial compositions contain...

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Bibliographic Details
Main Authors FEKETE PAL DR, VIRGULA JUDIT, FURDYGA EVA, LEVENTISZNE HUSZAR MAGDOLNA, KLEBOVICH IMRE DR, BALOGHNE NEMES KATALIN
Format Patent
LanguageEnglish
Published 30.08.2010
Subjects
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Summary:The object of the invention is to provide fluconazole containing capsules with improved active ingredient release. The in vitro dissolution as well as in vivo absorption of the fluconazole capsules according to the invention is faster and more consistent than those of commercial compositions containing fluconazole. The invention is based on the fact that granulation of fluconazole particles with an agent capable to provide hydrophilic surface, e.g. lactose, to said particles results in fast an consistent release of the active ingredient. In this way, capsules according to the invention are suitable to provide enhanced absorption of said active ingredient.
Bibliography:Application Number: HUP0302030