NOVEL PROCESS FOR PREPARING FLUCONAZOLE MONOHYDRATE

A new process is disclosed for the synthesis of fluconazole monohydrate and for crystal modifications of fluconazole which comprises the step of hydrolyzing a silyl ether of the formula (II) wherein R2 is hydrogen, or a C1 to C10 alkyl or phenyl group, R3 and R4 independently of each other are a C1...

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Main Authors NEHAI KREIDL JANOS, WERKNE PAPP EVA, SZANTAY CSABA DR, HEGEDUES ISTVAN, DEUTSCHNE JUHASZ IDA DR, CZIBULA LASZLO DR, FARKAS JENOENE DR, NAGYNE BAGDY JUDIT, PILLER AGNES
Format Patent
LanguageEnglish
Published 28.01.2010
Subjects
APPARATUS THEREFOR
CHEMISTRY
GENERAL METHODS OF ORGANIC CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Summary:A new process is disclosed for the synthesis of fluconazole monohydrate and for crystal modifications of fluconazole which comprises the step of hydrolyzing a silyl ether of the formula (II) wherein R2 is hydrogen, or a C1 to C10 alkyl or phenyl group, R3 and R4 independently of each other are a C1 to C10 alkyl or phenyl group in an aqueous solution, preferably at a pH below 3 or above 8.
Bibliography:Application Number: HU20050000796