PROCESS FOR PRODUCING AMORPHOUS ATORVASTATIN CALCIUM SALT

The invention relates to a process for the preparation of amorphous atorvastatin calcium by recrystallization of crude atorvastatin from an organic solvent which comprises dissolving crude amorphous atorvastatin calcium in a lower alkanol containing 2-4 carbon atoms or a mixture of such alkanols und...

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Bibliographic Details
Main Authors BARKOCZY JOZSEF DR, BARTHA FERENC, NAGY KALMAN DR, VERECZKEYNE DONATH GYOERGYI DR, GREFF ZOLTAN DR, KOTAY NAGY PETER DR, RATKAI ZOLTAN, SZENT KIRALLYI ZSUZSA, BALAZS LASZLO, SERES PETER DR, DOMAN IMRE, SIMIG GYULA DR
Format Patent
LanguageEnglish
Published 28.05.2009
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Summary:The invention relates to a process for the preparation of amorphous atorvastatin calcium by recrystallization of crude atorvastatin from an organic solvent which comprises dissolving crude amorphous atorvastatin calcium in a lower alkanol containing 2-4 carbon atoms or a mixture of such alkanols under heating and isolating the amorphous atorvastatin calcium precipitated after cooling. The atorvastatin calcium obtained is a known valuable agent useful in treating hyperlipidemia and hypercholesterolemia.
Bibliography:Application Number: HUP9903634