NOVEL 2H-PYRIDAZIN-3-ONE DERIVATIVES, PROCESS FOR THEIR PREPARATION, THEIR USE AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM

• Main Authors: BARKOCZY JOZSEF DR, SZENASI GABOR, RACZNE BAJNOGEL JUDIT, SCHMIDT EVA, KOTAY NAGY PETER DR, GACSALYI ISTVAN, LEVAY GYOERGY DR, PALLAGI KATALIN, WELLMANN JANOS DR, EGYED ANDRAS DR, SIMIG GYULA DR, MIKLOSNE KOVACS ANIKO
• Format: Patent
• Language: English
• Published: 28.01.2008
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

The invention refers to novel 2H-pyridazine-3-one derivatives of the formula I, pharmaceutical compositions containing the same and a process for the preparation of the active ingredient. The novel compounds possess neuroleptic effect and can be used, primarily, for the treatment of schizophrenia. In formula I, R stands for a hydrogen atom or a C1-4, alkyl group, X and Y represent, independently, a hydrogen atom, a halogen atom or a group of the formula II, with the proviso that one of X and Y means always a group of the formula II, and then the other one stands for a hydrogen atom or a halogen atom, wherein in formula II n has a value of 1 or 2.