PHOSPHORYLIZED DERIVATIVES OF 4-{4-[4-(HYDROXY-DIPHENYL)-1-PIPERIDINYL]-1-HYDROXY-BUTYL}-ALPHA-ALPHA-DIMETHYL-PHENYL-ACETIC ACID AND PROCESS FOR PRODUCING THEM
Preparation of piperidine derivatives of formula (II) comprises incubating alpha -(p-tert.-butylphenyl)-4-( alpha -hydroxy- alpha -phenylbenzyl)-1-piperidine butanol or optionally 4-(4-(4-hydroxydiphenyl)-1-piperidinyl)-1-hydroxybutyl)- alpha , alpha -dimethylacetic acid with a Cunninghamella or Abs...
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Main Authors | , |
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Format | Patent |
Language | English Hungarian |
Published |
28.12.2005
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Edition | 7 |
Subjects | |
Online Access | Get full text |
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Summary: | Preparation of piperidine derivatives of formula (II) comprises incubating alpha -(p-tert.-butylphenyl)-4-( alpha -hydroxy- alpha -phenylbenzyl)-1-piperidine butanol or optionally 4-(4-(4-hydroxydiphenyl)-1-piperidinyl)-1-hydroxybutyl)- alpha , alpha -dimethylacetic acid with a Cunninghamella or Absidia fungus. R1 = OH or CH2-O-P(O)(OH)2; and R2 = OH; or R1 = CH3; and R2 = -O-P(O)(OH)2; or R2 = -O-P(O)(OH)2; and R1 = COOH. Also claimed are: (i) (II) except that R1 is not OH when R2 is OH; and (ii) preparation of a piperazine derivative of formula (I) comprising incubating alpha -(p-tert.-butylphenyl)-4-( alpha -hydroxy- alpha -phenylbenzyl)-1-piperidine butanol with a Cunninghamella or Absidia fungus. |
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Bibliography: | Application Number: HUP9800511 |