ANTI-EGFR SINGLE-CHAIN FVS, ANTI-EGFR ANTIBODIES
PCT No. PCT/EP95/00978 Sec. 371 Date Nov. 17, 1995 Sec. 102(e) Date Nov. 17, 1995 PCT Filed Mar. 16, 1995 PCT Pub. No. WO95/25167 PCT Pub. Date Sep. 21, 1995This invention relates to new anti-EGFR antibodies and single-chain Fvs (scFvs) thereof which can be obtained from phage-antibody libraries con...
Saved in:
Main Authors | , , , , , , , , |
---|---|
Format | Patent |
Language | English Hungarian |
Published |
29.07.2002
|
Edition | 7 |
Subjects | |
Online Access | Get full text |
Cover
Loading…
Summary: | PCT No. PCT/EP95/00978 Sec. 371 Date Nov. 17, 1995 Sec. 102(e) Date Nov. 17, 1995 PCT Filed Mar. 16, 1995 PCT Pub. No. WO95/25167 PCT Pub. Date Sep. 21, 1995This invention relates to new anti-EGFR antibodies and single-chain Fvs (scFvs) thereof which can be obtained from phage-antibody libraries constructed from cells of an immunized mammalian, preferably a mouse. Two of the single-chain Fvs isolated from the phage-antibody libraries were engineered to create partially humanized whole antibody molecules. These chimeric anti-EGFR antibodies contain constant regions of human immunoglobulins, and can be used as well as the single-chain Fvs as agents for the diagnosis and therapy of human tumors. |
---|---|
Bibliography: | Application Number: HU19950003285 |