IMPROVED METHOD FOR PRODUCING N-PHENYL-N-METHOXI-ACETYL-D1-ALANINE-METHYLESTHER DERIVATIVES

Process for the preparation of N-phenyl-N-methoxyacetyl-DL-alanine methyl ester derivatives of the formula (I). (I) wherein R is a C1-4 alkyl residue; and n is a cardinal number between from 1 to 3, which comprises reacting an N-methoxyacetyl derivative of the formula (II). (II) wherein R and n are...

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Main Authors AGOCS,PAL,HU, BENCZIK,JANOSNE,HU, NAGY,LAJOS,HU, KRANITZ,TIBOR,HU, SOEPTEI,CSABA,HU, PELYVA,JENOE,HU, BALINT,SANDOR,HU, LEGRADI,LASZLO,HU, KOLONICS,ZOLTAN,HU, SEBOEK,DEZSOE,HU, CSEKE,JOLAN,HU
Format Patent
LanguageEnglish
Published 28.01.1994
Edition5
Subjects
ACYCLIC OR CARBOCYCLIC COMPOUNDS
CHEMISTRY
METALLURGY
ORGANIC CHEMISTRY
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Summary:Process for the preparation of N-phenyl-N-methoxyacetyl-DL-alanine methyl ester derivatives of the formula (I). (I) wherein R is a C1-4 alkyl residue; and n is a cardinal number between from 1 to 3, which comprises reacting an N-methoxyacetyl derivative of the formula (II). (II) wherein R and n are as defined above, with a stoichiometric amount of an alkaline metal alkoxide, at a temperature between 80 DEG C. and 150 DEG C., until completion of the removal of the alkanol present in the system, then reacting the thus obtained alkaline metal salt of the compound of formula (II) directly or after isolation with a methyl DL-x-halopropionate.
Bibliography:Application Number: HU19920001020