PROCESS FOR PRODUCING SUBSTITUTED PYRROLE DERIVATIVES

3-[ omega -(3,5-Di-t-butyl-4-hydroxyphenyl)alkanoyl]pyrroles and their de-oxy analogs, for example, 3-(3,5-di-t-butyl-4-hydroxybenzyl)pyrrole, 2-chloro-4-(3,5-di-t-butyl-4-hydroxybenzoyl)pyrrole, 3-(3,5-di-t-butyl-4-hydroxybenzoyl)pyrrole and 3-[2-(3,5-di-t-butyl-4-hydroxyphenyl)-1-oxoethyl]pyrrole,...

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Main Authors GARDNER,JOHN O.,US, MUCHOWSKI,JOSEPH M.,US, VICKERY,BRIAN H.,US, MURTHY,KRISHNA D. V.,US, GREENHOUSE,ROBERT J.,US, YOUNG,JOHN M.,US, CHIN,RUEIN,US, PRINCE,ANTHONY,US, PVZHITKOV,MOYSEY M.,US, WALKER,KEITH A. M.,US
Format Patent
LanguageEnglish
Published 28.09.1990
Edition5
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:3-[ omega -(3,5-Di-t-butyl-4-hydroxyphenyl)alkanoyl]pyrroles and their de-oxy analogs, for example, 3-(3,5-di-t-butyl-4-hydroxybenzyl)pyrrole, 2-chloro-4-(3,5-di-t-butyl-4-hydroxybenzoyl)pyrrole, 3-(3,5-di-t-butyl-4-hydroxybenzoyl)pyrrole and 3-[2-(3,5-di-t-butyl-4-hydroxyphenyl)-1-oxoethyl]pyrrole, are useful for the treatment of psoriasis or other allergic conditions such as conjunctivitis, bronchial asthma and inflammatory bronchial diseases; inflammatory bowel disease; inflammatory diseases; as analgesic and antipyretic agents; in bone diseases such as osteoporosis, periodontitis, tumor-related hypercalcemia, osteopetrosis, and Paget's Disease; and in ischemic heart disease including myocardial ischemia and myocardial infarction.
Bibliography:Application Number: HU19870004130