PROCESS FOR PRODUCING SULFUR-CONTAINING TRICYCLIC LACTAMS AND PHARMACEUTICAL COMPOSITIONS COMPRISING SAME AS ACTIVE INGREDIENT

This invention relates to conformationally rigid sulfur containing tricyclic lactams, of formula wherein R is hydrogen, alkyl, or arylalkyl, and R' is hydrogen or -COR, to the intermediates and processes useful for their preparation, and to their pharmacological effects in inhibiting angiotensi...

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Bibliographic Details
Main Authors BEIGHT,DOUGLAS W.,US, FLYNN,GARY A.,US
Format Patent
LanguageEnglish
Published 28.04.1990
Edition4
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:This invention relates to conformationally rigid sulfur containing tricyclic lactams, of formula wherein R is hydrogen, alkyl, or arylalkyl, and R' is hydrogen or -COR, to the intermediates and processes useful for their preparation, and to their pharmacological effects in inhibiting angiotensin converting enzyme, in treating reperfusion injury and in treating heart-failure.
Bibliography:Application Number: HU19880006576