PROCESS FOR PRODUCING CYTORODIN S DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS COMPRISING SAME

Cytorhodin S derivatives, especially cytorhodin S-immunoglobulin complexes are disclosed. Cytorhodin S itself possesses very high anticancer activity, but the complexes act more selectively on cancer cells and are more useful as an anticancer agent. In order to produce cytorhodin S-immunoglobulin co...

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Bibliographic Details
Main Authors SENDA,SHUNJI,JP, NUMATA,HITOKO,JP, WATANABE,HIROSHI,JP, USUI,JUNKO,JP, TONE,YUKIKO,JP, SUGAWARA,ISAMU,JP, OHKOUCHI,ETSUKO,JP, IWAHASHI,TOSHIRO,JP, OKAZAKI,HIROSHI,JP, FUKUDA,AKIO,JP, MATSUO,AKIHIKO,JP, KITAGAWA,HIROSHI,JP, KUROBANE,ITSUO,JP, BERSCHEID,HANS G.,DE
Format Patent
LanguageEnglish
Published 28.11.1989
Edition4
Subjects
CHEMISTRY
DERIVATIVES THEREOF
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
NUCLEIC ACIDS
NUCLEOSIDES
NUCLEOTIDES
ORGANIC CHEMISTRY
PEPTIDES
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
SUGARS
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Summary:Cytorhodin S derivatives, especially cytorhodin S-immunoglobulin complexes are disclosed. Cytorhodin S itself possesses very high anticancer activity, but the complexes act more selectively on cancer cells and are more useful as an anticancer agent. In order to produce cytorhodin S-immunoglobulin complexes, the oxo group on saccharide chain of cytorhodin S is reduced with an alkali metal cyanoborohydride in the presence of an ammonium salt or a compound having amino group to be converted to amino group or substituted amino group. Then, thus produced cytorhodin S derivatives are bound to immunoglobulin by means of a bifunctional cross-linking agent, a condensing agent or a spacer. New intermediate derivatives are also useful as an anticancer agent.
Bibliography:Application Number: HU19870002872