NEW PROCESS FOR PRODUCING PENEM DERIVATIVES

Compounds of the formula I : wherein R1 represents a hydroxy protecting group and R2 represents a carboxy protecting group, useful as intermediates for the preparation of penem antibiotics, are prepared by hydrolysing a compound of the formula II : wherein R1 and R2 are as defined above and R repres...

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Bibliographic Details
Main Authors FOA,MARCO,IT, DALLATOMASINA,FANCO,IT, CESTI, PIETRO,IT, CAMBIAGHI,STEFANO,IT, ALTAMURA,MARIA,IT, FRANCALANCI,FRANCO,IT, MARCHI,MARCELLO,IT
Format Patent
LanguageEnglish
Published 28.07.1989
Edition4
Subjects
ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM
BEER
BIOCHEMISTRY
CHEMISTRY
ENZYMOLOGY
FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE
HETEROCYCLIC COMPOUNDS
METALLURGY
MICROBIOLOGY
MUTATION OR GENETIC ENGINEERING
ORGANIC CHEMISTRY
SPIRITS
VINEGAR
WINE
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Summary:Compounds of the formula I : wherein R1 represents a hydroxy protecting group and R2 represents a carboxy protecting group, useful as intermediates for the preparation of penem antibiotics, are prepared by hydrolysing a compound of the formula II : wherein R1 and R2 are as defined above and R represents an alkyl, alkenyl or phenylalkyl group having from 1 to 18 carbon atoms, by means of an enzyme capable of se lectively hydrolysing the ester group of the 2-substituent thereof. d
Bibliography:Application Number: HU19870004639