PROCESS FOR PRODUCING CONDENSED TRICYCLIC LACTAME DERIVATIVES

The invention relates to 6-oxopyrido(2,1-α) and (1,4)thiazino(3,4-a)(2)benzazepine-4-carboxylic acid derivatives and their preparation and also to intermediates which can be used in the preparation. The said derivatives have a pharmacological effect by inhibiting angiotensin converting enzyme and th...

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Bibliographic Details
Main Authors ELYNN,GARY A.,US, BEIGHT,DOUGLAS W.,US
Format Patent
LanguageEnglish
Published 28.03.1989
Edition4
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:The invention relates to 6-oxopyrido(2,1-α) and (1,4)thiazino(3,4-a)(2)benzazepine-4-carboxylic acid derivatives and their preparation and also to intermediates which can be used in the preparation. The said derivatives have a pharmacological effect by inhibiting angiotensin converting enzyme and they can be used for treating hypertension. The novel compounds have the formula in which R and R1 are independently hydrogen; alkyl; substituted alkyl; aryl; substituted aryl; heteroaryl; or substituted heteroaryloxy; R2 is hydrogen, straight-chain or branched alkyl, alkenyl or alkinyl; cycloalkyl, arylalkyl; or substituted alkyl; R3 is H, alkyl, phenyl or benzyl; R4 is a natural amino acid residue, and R3 and R4 have been linked, by way of the carbon atoms to which they are bonded, in order to form a 6-8-membered condensed ring which optionally contains a sulfur or oxygen atom, and R5 and R6 are independently hydrogen, hydroxyl; halogen; alkyl; or alkyloxy.
Bibliography:Application Number: HU19870002684