PROCESS FOR PRODUCTION OF HYDROXAME-ACID-DERIVATIVES AND MEDICAL COMPOSITIONS CONTAINING THEM

Hydroxamates are provided having the structure wherein R1 is hydrogen, lower alkyl, aryl, lower alkenyl, cycloalkenyl, aralkyl, or wherein n is 1 to 4 and X is hydroxy, alkoxy, amino, C1-C4-alkylamino or C1-C4-dialkylamino. R2 is hydrogen or lower alkyl; and R3 is C1-C20 alkyl or C3-C20 alkenyl, ary...

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Bibliographic Details
Main Authors KARANEWSKY,DONALD S.,US, HASLANGER,MARTIN F.,US
Format Patent
LanguageEnglish
Published 28.02.1989
Edition4
Subjects
ACYCLIC OR CARBOCYCLIC COMPOUNDS
BEER
BIOCHEMISTRY
CHEMISTRY
COMPOSITIONS THEREOF
CULTURE MEDIA
ENZYMOLOGY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
MICROBIOLOGY
MICROORGANISMS OR ENZYMES
MUTATION OR GENETIC ENGINEERING
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
SPIRITS
VINEGAR
WINE
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Summary:Hydroxamates are provided having the structure wherein R1 is hydrogen, lower alkyl, aryl, lower alkenyl, cycloalkenyl, aralkyl, or wherein n is 1 to 4 and X is hydroxy, alkoxy, amino, C1-C4-alkylamino or C1-C4-dialkylamino. R2 is hydrogen or lower alkyl; and R3 is C1-C20 alkyl or C3-C20 alkenyl, aryl, aryl-alkyl, cycloalkyl, aryl-alkenyl, lower alkoxy, lower alkenyloxy, aryl-alkoxy or cycloalkyloxy, and m is 0 to 5. These compounds are useful as inhibitors of DELTA 5-lipoxygenase and as such are useful as antiallergy agents.
Bibliography:Application Number: HU19860001422