PROCESS FOR PREPARING 7-ACETAMIDO-3-METHYL-CEF-3-EME-4-CARBOXYLIC ACID DERIVATIVES

A novel cephalosporin derivative of the formula: [wherein X is hydrogen, hydroxyl, acyloxy, alkoxy, carbamoyloxy, quaternary ammonium or a group of the formula -SR1 (where R1 is a nitrogen-containing heterocyclic group)] or a pharmaceutically acceptable salt or ester thereof is found to have potent...

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Bibliographic Details
Main Authors MINAMIDA,ISAO,JP, NISHIMURA,TATSUO,JP, SHIRAISHI,MITSURU,JP, YAMAOKA,MASAYOSHI,JP, NUMATA,MITSUO,JP
Format Patent
LanguageEnglish
Published 29.11.1982
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:A novel cephalosporin derivative of the formula: [wherein X is hydrogen, hydroxyl, acyloxy, alkoxy, carbamoyloxy, quaternary ammonium or a group of the formula -SR1 (where R1 is a nitrogen-containing heterocyclic group)] or a pharmaceutically acceptable salt or ester thereof is found to have potent antibiotic activity against various bacteria, particularly against gram-negative bacteria such as Escherichia coli, Klebsiella pneumoniae, Proteus vulgaris, Proteus mirabilis, Proteus morganii, Proteus rettgeri and Citrobacter freundii.
Bibliography:Application Number: HU1977TA01433