PROCESS AND ANTIPARASTIC INTERMEDIATES FOR DORAMECTIN

PCT No. PCT/IB94/00283 Sec. 371 Date Mar. 8, 1996 Sec. 102(e) Date Mar. 8, 1996 PCT Filed Sep. 19, 1994 PCT Pub. No. WO95/09863 PCT Pub. Date Apr. 13, 1995Intermediates and a process for preparing doramectin, the compound of formula (I), semisynthetically from by-product in the fermentation procedur...

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Bibliographic Details
Main Authors NEIL DEMERS, CHARLES W. MURTIASHAW, CONSTANTINE SKLAVOUNOS, THOMAS C. CRAWFORD, STEPHEN P. GIBSON
Format Patent
LanguageEnglish
Published 30.06.1997
Edition6
Subjects
AGRICULTURE
ANIMAL HUSBANDRY
BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES, AS HERBICIDES
CHEMISTRY
DERIVATIVES THEREOF
FISHING
FORESTRY
HUMAN NECESSITIES
HUNTING
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
NUCLEIC ACIDS
NUCLEOSIDES
NUCLEOTIDES
ORGANIC CHEMISTRY
PEST REPELLANTS OR ATTRACTANTS
PLANT GROWTH REGULATORS
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTSTHEREOF
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
SUGARS
TRAPPING
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Summary:PCT No. PCT/IB94/00283 Sec. 371 Date Mar. 8, 1996 Sec. 102(e) Date Mar. 8, 1996 PCT Filed Sep. 19, 1994 PCT Pub. No. WO95/09863 PCT Pub. Date Apr. 13, 1995Intermediates and a process for preparing doramectin, the compound of formula (I), semisynthetically from by-product in the fermentation procedure which also yields the compound of formula (I). The intermediates prepared by the process of this invention also have utility as antiparasitic agents. The process of this invention utilizes continuous reaction inert gas sparging during the pyrolysis step, resulting in a significant improvement in the overall yield of this conversion. (I)
Bibliography:Application Number: HR1994P000642