ANTI-TROP2 ANTIBODY-DRUG CONJUGATE

Provided is a method for producing an antibody-drug conjugate comprising reacting a compound represented by the following formula: (maleimid-N-yl)-(CH 2 )n 3 -C(=O)-L 2 -L P -NH-(CH 2 )n 1 -L a -(CH 2 )n 2 - C(=O)-(NH-DX) with an anti-TROP2 antibody or a reactive derivative thereof...

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Main Authors	Takahashi, Shu, Yamaguchi, Miki, Hamada, Hirofumi, Agatsuma, Toshinori, Hasegawa, Jun, Okajima, Daisuke
Format	Patent
Language	Croatian English
Published	22.02.2019
Subjects	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING ORGANIC CHEMISTRY PEPTIDES PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SPIRITS VINEGAR WINE
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Summary:	Provided is a method for producing an antibody-drug conjugate comprising reacting a compound represented by the following formula: (maleimid-N-yl)-(CH 2 )n 3 -C(=O)-L 2 -L P -NH-(CH 2 )n 1 -L a -(CH 2 )n 2 - C(=O)-(NH-DX) with an anti-TROP2 antibody or a reactive derivative thereof and conjugating a drug-linker moiety to the antibody by a method for forming a thioether bond at a disulfide bond site present in a hinge part of the antibody.
Bibliography:	Application Number: HR2019P000056T