MACROCYCLIC DERIVATIVES FOR THE TREATMENT OF PROLIFERATIVE DISEASES

The invention relates to compounds of formula (Φ) as further defined herein and to the pharmaceutically acceptable salts thereof, to pharmaceutical compositions comprising such compounds and salts, and to the uses thereof. The compounds and salts of the present invention inhibit anaplastic lymphoma...

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Bibliographic Details
Main Authors Burke, Benjamin Joseph, Hoffman, Robert Louis, Palmer, Cynthia Louise, Deal, Judith Gail, Sach, Neal William, Collins, Michael Raymond, Cui, Jingrong Jean, Kath, John Charles, Le, Phuong Thi Quy, Huang, Qinhua, Johnson, Ted William, Bailey, Simon, Kania, Robert Steven, Richardson, Paul Francis, McTigue, Michele Ann
Format Patent
LanguageCroatian
English
Published 21.04.2017
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:The invention relates to compounds of formula (Φ) as further defined herein and to the pharmaceutically acceptable salts thereof, to pharmaceutical compositions comprising such compounds and salts, and to the uses thereof. The compounds and salts of the present invention inhibit anaplastic lymphoma kinase (ALK) and/or EML4-ALK and are useful for treating or ameliorating abnormal cell proliferative disorders, such as cancer.
Bibliography:Application Number: HR2017P000287T