COMPOSITIONS OF PROKARYOTIC PHENYLALANINE AMMONIA-LYASE AND METHODS OF USING SAID COMPOSITIONS

The invention provides a prokaryotic phenylalanine ammonia-lyase (PAL) variant, wherein said PAL variant has a greater phenylalanine-converting activity and/or a reduced immunogenicity as compared to a wild-type PAL as well as a pharmaceutical composition comprising same. Further provided is the use...

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Bibliographic Details
Main Authors WENDT, DANIEL J, KAKKIS, EMIL D, VELLARD, MICHEL C, FITZPATRICK, PAUL A
Format Patent
LanguageCroatian
English
Published 18.12.2015
Subjects
BEER
BIOCHEMISTRY
CHEMISTRY
COMPOSITIONS THEREOF
CULTURE MEDIA
ENZYMOLOGY
METALLURGY
MICROBIOLOGY
MICROORGANISMS OR ENZYMES
MUTATION OR GENETIC ENGINEERING
PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS
SPIRITS
VINEGAR
WINE
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Summary:The invention provides a prokaryotic phenylalanine ammonia-lyase (PAL) variant, wherein said PAL variant has a greater phenylalanine-converting activity and/or a reduced immunogenicity as compared to a wild-type PAL as well as a pharmaceutical composition comprising same. Further provided is the use of the PAL variant for treating a disease in a subject caused all or in part by a deficiency in phenylalanine hydroxylase (PAH), for treating classic severe PKU in a subject or an infant of between 0 and 3 years having PKU, or for treating a pregnant female having hyperphenylalaninemia (HPA), wherein the PAL variant is administered in combination with a protein-restricted diet.
Bibliography:Application Number: HR2015P001268T