AZETIDINES AS MEK INHIBITORS FOR THE TREATMENT OF PROLIFERATIVE DISEASES
Spoj formule I: ili pojedinačni stereoizomer ili smjesa stereoizomera, ili po izboru njegova farmaceutski prihvatljiva sol ili solvat, naznačen time što su A, X, R1, R2, R3, R4, R5, R6 i R7 kako je definirano za grupu A, grupu B, grupu C ili grupu D: Grupa A: A je arilen po izboru supstituiran s jed...
Saved in:
Main Authors | , , , , , , , , , , , , , , , , |
---|---|
Format | Patent |
Language | Croatian English |
Published |
31.08.2011
|
Subjects | |
Online Access | Get full text |
Cover
Loading…
Abstract | Spoj formule I: ili pojedinačni stereoizomer ili smjesa stereoizomera, ili po izboru njegova farmaceutski prihvatljiva sol ili solvat, naznačen time što su A, X, R1, R2, R3, R4, R5, R6 i R7 kako je definirano za grupu A, grupu B, grupu C ili grupu D: Grupa A: A je arilen po izboru supstituiran s jednom, dvije, tri ili četiri skupine izabrane između R10, R12, R14 iR16 gdje su R1O, R12, R14 i R16 nezavisno jedan od drugog vodik, alkil, alkenil, alkinil, halogen, halogenalkoksi, hidroksi, alkoksi, amino, alkilamino, dialkilamino, halogenalkil, -NHS(O)2R8, -CN, -C(O)R8, -C(O)OR8, -C(O)NR8R8' i -NR8C(O)R8'; X je alkil, halogen, halogenalkil ili halogenalkoksi; R1, R2, R3, R4, R5 i R6 su nezavisno vodik, halogen, nitro, NR8R8', -OR8, -NHS(O)2R8, -CN, -S(O)mR8,
Disclosed are compounds of Formula (I) and pharmaceutically acceptable salts and solvates thereof. Such compounds are MEK inhibitors and are useful in the treatment of proliferative diseases, such as cancer. Also disclosed are pharmaceutical compositions containing such compounds as well as methods of using the compounds and compositions of the invention in the treatment of cancer. |
---|---|
AbstractList | Spoj formule I: ili pojedinačni stereoizomer ili smjesa stereoizomera, ili po izboru njegova farmaceutski prihvatljiva sol ili solvat, naznačen time što su A, X, R1, R2, R3, R4, R5, R6 i R7 kako je definirano za grupu A, grupu B, grupu C ili grupu D: Grupa A: A je arilen po izboru supstituiran s jednom, dvije, tri ili četiri skupine izabrane između R10, R12, R14 iR16 gdje su R1O, R12, R14 i R16 nezavisno jedan od drugog vodik, alkil, alkenil, alkinil, halogen, halogenalkoksi, hidroksi, alkoksi, amino, alkilamino, dialkilamino, halogenalkil, -NHS(O)2R8, -CN, -C(O)R8, -C(O)OR8, -C(O)NR8R8' i -NR8C(O)R8'; X je alkil, halogen, halogenalkil ili halogenalkoksi; R1, R2, R3, R4, R5 i R6 su nezavisno vodik, halogen, nitro, NR8R8', -OR8, -NHS(O)2R8, -CN, -S(O)mR8,
Disclosed are compounds of Formula (I) and pharmaceutically acceptable salts and solvates thereof. Such compounds are MEK inhibitors and are useful in the treatment of proliferative diseases, such as cancer. Also disclosed are pharmaceutical compositions containing such compounds as well as methods of using the compounds and compositions of the invention in the treatment of cancer. |
Author | ANAGHA ABHIJIT JOSHI CSABA J. PETO CHARLES M. BLAZEY KENNETH D. RICE ANGIE INYOUNG KIM ELENA KOLTUN JEAN-CLAIRE LIMUN MANALO STEVEN CHARLES DEFINA NEEL KUMAR ANAND JOERG BUSSENIUS OWEN JOSEPH BOWLES ABIGAIL R. KENNEDY JEFFRY KIMO CURTIS NAING AAY TSZE H. TSANG SIMONA COSTANZO LARISA DUBENKO |
Author_xml | – fullname: JOERG BUSSENIUS – fullname: JEAN-CLAIRE LIMUN MANALO – fullname: CHARLES M. BLAZEY – fullname: NEEL KUMAR ANAND – fullname: JEFFRY KIMO CURTIS – fullname: SIMONA COSTANZO – fullname: ELENA KOLTUN – fullname: OWEN JOSEPH BOWLES – fullname: TSZE H. TSANG – fullname: ANGIE INYOUNG KIM – fullname: LARISA DUBENKO – fullname: CSABA J. PETO – fullname: ABIGAIL R. KENNEDY – fullname: NAING AAY – fullname: STEVEN CHARLES DEFINA – fullname: ANAGHA ABHIJIT JOSHI – fullname: KENNETH D. RICE |
BookMark | eNqNyr0KwjAQAOAMOvj3DgfOQqMddIz2Qg5tU3KHg0spck6SFur74-IDOH3LtzSzPGRdmOAeKFRRgwyOocYrUBPoTBITg48JJCBIQic1NgLRQ5vijTwmJ3RHqIjRMfLazF_9e9LNz5XZepRL2Ok4dDqN_VOzfrqQ2n1hbVGejiL28N_6AvO7MB8 |
ContentType | Patent |
DBID | EVB |
DatabaseName | esp@cenet |
DatabaseTitleList | |
Database_xml | – sequence: 1 dbid: EVB name: esp@cenet url: http://worldwide.espacenet.com/singleLineSearch?locale=en_EP sourceTypes: Open Access Repository |
DeliveryMethod | fulltext_linktorsrc |
Discipline | Medicine Chemistry Sciences |
DocumentTitleAlternate | AZETIDINI KAO INHIBITORI MEK ZA LIJEČENJE PROLIFERATIVNIH BOLESTI |
ExternalDocumentID | HRP20110498TT1 |
GroupedDBID | EVB |
ID | FETCH-epo_espacenet_HRP20110498TT13 |
IEDL.DBID | EVB |
IngestDate | Fri Jul 19 12:57:35 EDT 2024 |
IsOpenAccess | true |
IsPeerReviewed | false |
IsScholarly | false |
Language | Croatian English |
LinkModel | DirectLink |
MergedId | FETCHMERGED-epo_espacenet_HRP20110498TT13 |
Notes | Application Number: HR2011P000498T |
OpenAccessLink | https://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20110831&DB=EPODOC&CC=HR&NR=P20110498T1 |
ParticipantIDs | epo_espacenet_HRP20110498TT1 |
PublicationCentury | 2000 |
PublicationDate | 20110831 |
PublicationDateYYYYMMDD | 2011-08-31 |
PublicationDate_xml | – month: 08 year: 2011 text: 20110831 day: 31 |
PublicationDecade | 2010 |
PublicationYear | 2011 |
RelatedCompanies | EXELIXIS |
RelatedCompanies_xml | – name: EXELIXIS |
Score | 2.8187828 |
Snippet | Spoj formule I: ili pojedinačni stereoizomer ili smjesa stereoizomera, ili po izboru njegova farmaceutski prihvatljiva sol ili solvat, naznačen time što su A,... |
SourceID | epo |
SourceType | Open Access Repository |
SubjectTerms | CHEMISTRY HETEROCYCLIC COMPOUNDS METALLURGY ORGANIC CHEMISTRY |
Title | AZETIDINES AS MEK INHIBITORS FOR THE TREATMENT OF PROLIFERATIVE DISEASES |
URI | https://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20110831&DB=EPODOC&locale=&CC=HR&NR=P20110498T1 |
hasFullText | 1 |
inHoldings | 1 |
isFullTextHit | |
isPrint | |
link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwfV3dS8MwED_GFPVNp-J0SkDpW5Gt7do9FOnalFTdWro4hi9jbVoQoRuu4r_vJWzOp72FHBzHwX0m9zuAB-HY5ULkjm6IgaOb-cLUF2XZ1y2zKIVRYpKg4ItH4z57M59n1qwBn9tZGIUT-qPAEdGicrT3Wvnr1a6JFai_levH7AOvlk8hdwNNbNt9cnGWFgxdmsRB7Gu-77JUG6duoojmwOFYKh1gHm1Lc6DToRxLWf2PKeEpHCbIrqrPoFFULTj2t6vXWnA02rx443FjfOtzYN475VEg12QQb0JG9IVEYxYNIx6nE4LVHOGMEp5Sj0uEfhKHJEnj1yikshE1pSSIJtRD_3kB9yHlPtNRpPmfAuYs3YnPu8YlNKtlVVwB6Yusm-US9Q2zgswoMPmwesKyJQiMXVq9NnT2cbreT76Bk10HtQPN-uu7uMUQXGd3SnW_iJ2EDw |
link.rule.ids | 230,309,783,888,25576,76876 |
linkProvider | European Patent Office |
linkToHtml | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwfV3dS8MwED_GFOebTsXp1IDStyJb27V7KNK1KYlbP-jiGL6M9QtE6Iar-O-bhM35tLeQg-M4uM_kfgfwlFtmucwzS9XyoaXq2VJXl2U5UA29KHOt5EmChC8OwgF501_nxrwBn7tZGIkT-iPBEblFZdzea-mv1_smlif_Vm6e0w9-tXrxme0p-a7dJxZnKd7IxnHkRa7iujZJlDCxY0nUhxbjpdIRz7FNYQ54NhJjKev_McU_g-OYs6vqc2gUVRta7m71WhtOgu2LNz9ujW9zAcR5x4x6Yk0GcqYowGNEQ0JHlEXJFPFqDjGCEUuwwwRCP4p8FCfRhPpYNKJmGHl0ih3uPy_h0cfMJSoXafGngAVJ9uKznnYFzWpVFdeABnnaSzOB-sazglQrePJh9HPDFCAwZmn0O9A9xOnmMPkBWoQFk8WEhuNbON13U7vQrL--izsejuv0XqrxF-ZMhwI |
openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Apatent&rft.title=AZETIDINES+AS+MEK+INHIBITORS+FOR+THE+TREATMENT+OF+PROLIFERATIVE+DISEASES&rft.inventor=JOERG+BUSSENIUS&rft.inventor=JEAN-CLAIRE+LIMUN+MANALO&rft.inventor=CHARLES+M.+BLAZEY&rft.inventor=NEEL+KUMAR+ANAND&rft.inventor=JEFFRY+KIMO+CURTIS&rft.inventor=SIMONA+COSTANZO&rft.inventor=ELENA+KOLTUN&rft.inventor=OWEN+JOSEPH+BOWLES&rft.inventor=TSZE+H.+TSANG&rft.inventor=ANGIE+INYOUNG+KIM&rft.inventor=LARISA+DUBENKO&rft.inventor=CSABA+J.+PETO&rft.inventor=ABIGAIL+R.+KENNEDY&rft.inventor=NAING+AAY&rft.inventor=STEVEN+CHARLES+DEFINA&rft.inventor=ANAGHA+ABHIJIT+JOSHI&rft.inventor=KENNETH+D.+RICE&rft.date=2011-08-31&rft.externalDBID=T1&rft.externalDocID=HRP20110498TT1 |