AZETIDINES AS MEK INHIBITORS FOR THE TREATMENT OF PROLIFERATIVE DISEASES

• Main Authors: JOERG BUSSENIUS, JEAN-CLAIRE LIMUN MANALO, CHARLES M. BLAZEY, NEEL KUMAR ANAND, JEFFRY KIMO CURTIS, SIMONA COSTANZO, ELENA KOLTUN, OWEN JOSEPH BOWLES, TSZE H. TSANG, ANGIE INYOUNG KIM, LARISA DUBENKO, CSABA J. PETO, ABIGAIL R. KENNEDY, NAING AAY, STEVEN CHARLES DEFINA, ANAGHA ABHIJIT JOSHI, KENNETH D. RICE
• Format: Patent
• Language: Croatian; English
• Published: 31.08.2011
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; METALLURGY; ORGANIC CHEMISTRY

Spoj formule I: ili pojedinačni stereoizomer ili smjesa stereoizomera, ili po izboru njegova farmaceutski prihvatljiva sol ili solvat, naznačen time što su A, X, R1, R2, R3, R4, R5, R6 i R7 kako je definirano za grupu A, grupu B, grupu C ili grupu D: Grupa A: A je arilen po izboru supstituiran s jednom, dvije, tri ili četiri skupine izabrane između R10, R12, R14 iR16 gdje su R1O, R12, R14 i R16 nezavisno jedan od drugog vodik, alkil, alkenil, alkinil, halogen, halogenalkoksi, hidroksi, alkoksi, amino, alkilamino, dialkilamino, halogenalkil, -NHS(O)2R8, -CN, -C(O)R8, -C(O)OR8, -C(O)NR8R8' i -NR8C(O)R8'; X je alkil, halogen, halogenalkil ili halogenalkoksi; R1, R2, R3, R4, R5 i R6 su nezavisno vodik, halogen, nitro, NR8R8', -OR8, -NHS(O)2R8, -CN, -S(O)mR8, Disclosed are compounds of Formula (I) and pharmaceutically acceptable salts and solvates thereof. Such compounds are MEK inhibitors and are useful in the treatment of proliferative diseases, such as cancer. Also disclosed are pharmaceutical compositions containing such compounds as well as methods of using the compounds and compositions of the invention in the treatment of cancer.