AMIDE DERIVATIVES BEARING A CYCLOPROPYLAMINOACARBONYL SUBSTITUENT USEFUL AS CYTOKINE INHIBITORS

• Main Authors: JOHN GRAHAM CUMMING, IAN ALUN NASH, DEARG SUTHERLAND BROWN
• Format: Patent
• Language: Croatian; English
• Published: 31.12.2010
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

Spoj Formule I, naznačen time, štoQa je fenil ili heteroaril, i Qa može opcijski nositi 1 ili 2 supstituenta odabrana između hidroksi, halogeno, trifluorometil, cijano, amino, (1-6C)alkil, (2-6C)alkenil, (2-6C)alkinil, (1-6C)alkoksi, (1-6C)alkilamino, di-[(1-6C)alkil]amino i (1-6C) alkoksikarbonil; R1 i R2 su svaki nezavisno odabrani iz grupe koja sadrži vodik, (1-6C)alkil, (2-6C)alkenil i (2-6C)alkinil; iQb je fenil, heteroaril ili heterociklil, i Qb može opcijski nositi 1 ili 2 supstituenta odabrana između hidroksi, halogeno, (1-6C)alkil, (2-6C)alkenil, (2-6C)alkinil, (3-6C)cikloalkil, (3-6C)cikloalkil-(1-6C)alkil, (1-6C)alkoksi, (3-6C)cikloalkoksi, (3-6C)cikloalkil-(1-6C)alkoksi, karboksi, (1-6C)alkoksikarbonil, N-(1-6C)alkilkarbamoil, N,N-di-[(1-6C)alkil]karbamoil, (2-6C)alkanoil, amino, (1-6C)alkilamino, di-[(1-6C)alkil]amino, halogeno-(1-6C)alkil, hidroksi-(1-6C)alkil, (1-6C)alkoksi-(1-6C)alkil, cijano-(1-6C)alkil, amino-(1-6C)alkil, (1-6C)alkilamino-(1-6C)alkil, di-[(1-6C)alkil]amino-(1-6C)alkil, (1-6C)alkiltio, (1-6C)alkilsulfinil, (1-6C)alkilsulfonil, aminosulfonil, N-(1-6C)alkilsulfamoil, N,N-di-[(1-6C)alkil]sulfamoil i (3-6C) cikloalkilsulfonil; i gdje svaki od supstituenata na Qa ili Qb, definirano ovdje gore, koji uključuju CH2 grupu koja je pridružena za 2 ugljikova atoma ili CH3 grupu koja je pridružena za ugljikov atom može opcijski nositi na svakoj spomenutoj CH2 ili CH3 grupi jedan ili više supstituenata odabranih između hidroksi, cijano, amino, (1-6C)alkil, (1-6C)alkoksi, (1-6C)alkilamino i di-[(1-6C) alkil]amino; ili njihovu farmaceutski prihvatljivu sol. Patent sadrži još 16 patentnih zahtjeva. The invention concerns a compound of the Formula (I), wherein Qa is heteroaryl and is substituted with halogeno; R1 and R2 are hydrogen; and Qb is phenyl or heteroaryl, and Qb may optionally bear 1 or 2 substituents selected from hydroxy, halogeno and (1-6C)alkyl, or a pharmaceutically-acceptable salt thereof; processes for their preparation, pharmaceutical compositions containing them and their use in the treatment of diseases or medical conditions mediated by cytokines.