ISOSTRUCTURAL PSEUDOPOLYMORPHS OF 9-DEOXO-9A-AZA-9A-METHYL-9A-HOMOERYTHROMYCINA

A substantially pure isostructural pseudopolymorph of 9-deoxo-9a-aza-9a-methyl-9a-homoerythromycin A having the Formula I: wherein S is an organic solvent which is at least partially miscible with water, x is 1, y is 0, 0.5, or 1, the pseudopolymorph being characterized by the monoclinic space group...

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Main Authors DARKO FILIC, GORJANA LAZAREVSKI, ALEKSANDAR DANILOVSKI, DOMINIK CINEIC, MILJENKO DUMIC, ALOJZ DUMBOVIC, ERNEST MEUETROVIC, KATICA LAZARIC, DEJAN-KREUEIMIR BUEAR, MARINA OREUEIC, MLADEN VINKOVIC, ZDRAVKA KNEŽEVIC
Format Patent
LanguageEnglish
Published 30.06.2005
Edition7
Subjects
CHEMISTRY
DERIVATIVES THEREOF
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
NUCLEIC ACIDS
NUCLEOSIDES
NUCLEOTIDES
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
SUGARS
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Summary:A substantially pure isostructural pseudopolymorph of 9-deoxo-9a-aza-9a-methyl-9a-homoerythromycin A having the Formula I: wherein S is an organic solvent which is at least partially miscible with water, x is 1, y is 0, 0.5, or 1, the pseudopolymorph being characterized by the monoclinic space group P 2 1 and average unit cell parameters comprising: crystal axis lengths of a = 15.5 - 17.0 Å, b = 15.5 - 17.0 Å and c = 17.5 - 19.5 Å, and angles between the crystal axes of ± = ³ = 90° and ² = 106° - 112°.
Bibliography:Application Number: HR2004P000858