PLATINUM COMPLEX, ITS PREPARATION AND THERAPEUTIC APPLICATION

• Main Authors: FRANTIUEEK AEAK, ANNA POULOVA, DANA ZALUSKA, MILAN MELKA, ADOLF MISTR, JAROSLAV TURANEK
• Format: Patent
• Language: English
• Published: 31.07.2006
• Subjects: ACYCLIC OR CARBOCYCLIC COMPOUNDS; ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM; CHEMISTRY; COMPOSITIONS BASED THEREON; DERIVATIVES THEREOF; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; ORGANIC MACROMOLECULAR COMPOUNDS; POLYSACCHARIDES; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS; THEIR PREPARATION OR CHEMICAL WORKING-UP

Kompleks platine s oksidacijskim brojem IV formule (I), naznačen time, da X predstavlja halogeni atom, B predstavlja, neovisno jedno o drugome, halogeni atom, hidroksilnu skupinu ili karboksilnu skupinu koja sadržava od 1 do 6 atoma ugljika, teA predstavlja -NH2-R skupinu, u kojoj je R triciklična ugljikovodična struktura koja sadržava od 10 do 14ugljikovih atoma, koja, po izboru, može biti supstituirana s jednom ili dvije alkilne skupine na tricikličnom prstenu, pri čemu svaka skupina ima od 1 do 4 ugljikova atoma. Patent sadrži još 7 patentnih zahtjeva. Disclosed is a platinum complex of formula (I) wherein X represents a halogen atom, B represent, independently to each other, a halogen atom, a hydroxyl group or a carboxylate group containing 1 to 6 carbon atoms, and A represents a croup -NH2-R wherein R is a tricyclic hydrocarbon moiety containing 10 to 14 carbon atoms which may be optionally substituted on the tricyclic ring by one or two alkyl group(s) each containing 1 to 4 carbon atoms, and, furthermore, an inclusion complex of the above platinum complex with beta- or gamma-cyclodextrin which may be optionally substituted by hydroxyalkyl groups containing 1 to 6 carbon atoms. There is also disclosed a process for the manufacture of the complex of formula (I) based on oxidation of a complex of divalent platinum of formula (II) with hydrogen peroxide and on optional substitution of hydroxyl groups in the obtained product with carboxylate groups by action of an acylating agent. The disclosed complexes may be used as such or as a part of pharmaceutical composition in a therapy of oncologic diseases.