HIGH PURITY (1R,2S,4R)-(-)-2-[(2'-{N,N-DIMETHYLAMINO}-ETHOXY)]-2-[PHENYL]-1,7,7-TRI-[METHYL]-BICYCLO [2.2.1] HEPTANE AND PHARMACEUTICALLY ACCEPTABLE ACID ADDITION SALTS THEREOF AND A PROCESS FOR THE PREPARATION OF THESE COMPOUNDS AS WELL AS MEDICAMENTS CONTAINING 1OR MORE OF THESE COMPOUNDS AND TH

• Main Authors: TIBOR MEZEI, ZOLTAN BUDAI, NORBERT NUMETH, GYULA LUKACS, JANOS SZULAGYI, GYULA SIMIG, MARTA PORCS-MAKKAY, KALMAN NAGY, GYOERGYI DONATH VERECZEKEY, GYOERGY KRASZNAI, TIBOR SZABO
• Format: Patent
• Language: Croatian; English
• Published: 31.08.2007
• Subjects: ACYCLIC OR CARBOCYCLIC COMPOUNDS; CHEMISTRY; METALLURGY; ORGANIC CHEMISTRY

Postupak za proizvodnju (1R,2S,4R)-(-)2-[2'{N,N-dimetilamino}-etoksi)-2[fenil]-1,7,7-tri-[metil]-biciklo[2.2.1]heptana formulei njegovih farmaceutskiprihvatljivih kiselinskih adicijskih soli konverzijom (+)-1,7,7-tri-[metil]-biciklo[2.2.l]heptan-2-ona {(+)-kamfor} formuleu (1R,2S,4R)-(-)-2-[fenil]-1,7,7-tri-[metil]-biciklo[2.2.1]heptan-2-ol formulereakcijom prethodnog s fenil magnezijevim halidom ili fenil alkalnim spojevima, i ukoliko je neophodno provođenjem hidrolize produkta rekacije, i reakcijom (1R,2S;4R)-(-)-2-[fenil]-1,7,7-tri-[metil]-biciklo[2.2.1]heptan-2-ol formule III dobivenog na prethodno opisan način s (2-{halogeno}-etil)-dimetilaminom u prisustvu hidrida alkalnog metala iliamida alkalnog metala u organskom otapalu, i ukoliko je poželjno, konverzijom baze (1R,2S,4R)-(-)2-[2'{N,N-dimetilamino}-etoksi)-2[fenil]-1,7,7-tri-[metil]-biciklo[2.2.1] heptana formule I dobivene na prethodno-opisan način u sol, naznačen time da se reakcija između (1R,2S,4R)-(-)-2-[fenil]-1,7,7-tri-[metil]-biciklo[2.2.1]heptan-2-ol formule III i(2-{halogeno}-etil)-dimetilamina odvija u mediju koji kao otapalo/otapala sadrži 1 ili više spojevakoji imaju 5- ili 6-člani zasićeni heterocikličkiprsten s 2 kisikova atoma u prstenu. Patent sadrži još 8 patentnih zahtjeva. The invention relates to high purity (1R,2S,4R)-(-)-2-[(2'-{N,N-dimethylamino}-ethoxy)]-2-[phenyl]-1,7,7-tri-[methyl]-bicyclo[2.2.1]heptane and pharmaceutically acceptable acid addition salts thereof containing not more than 0.2% of (1R,3S,4R)-3-[(2'-{N,N-dimethylamino}-ethyl)]-1,7,7-tri-[methyl]-bicyclo[2.2.1]heptane-2-one and/or of a pharmaceutically acceptable acid addition salt thereof.Furthermore the invention is concerned with a process for the preparation of these compounds.Moreover the invention relates to medicaments containing 1 or more of these compounds and their use.