ALQUINOS COMO INHIBIDORES DE METODO PROTEINASA MATRIZ

LA PRESENTE INVENCION SE REFIERE A ALQUINOS COMO INHIBIDORES DE METODO PROTEINASA MATRIZ A compound of Formula Ior a pharmaceutically acceptable salt thereof, or a tautomer thereof, wherein G1, G2, and B are as defined in the application, are selective inhibitors of MMP-13. The compounds are useful...

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Bibliographic Details
Main Authors AMY MAE BUNKER, WILLIAM GLEN HARTER, JAMES LESTER HICKS, LY THI PHAM, JOSEPH ARMAND PICARD, WILLIAM HOWARD ROARK, PATRICK MICHAEL O'BRIEN
Format Patent
LanguageSpanish
Published 20.12.2002
Subjects
ACYCLIC OR CARBOCYCLIC COMPOUNDS
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:LA PRESENTE INVENCION SE REFIERE A ALQUINOS COMO INHIBIDORES DE METODO PROTEINASA MATRIZ A compound of Formula Ior a pharmaceutically acceptable salt thereof, or a tautomer thereof, wherein G1, G2, and B are as defined in the application, are selective inhibitors of MMP-13. The compounds are useful for treating diseases mediated by MMP-13, including cancer and arthritis.
Bibliography:Application Number: HN20020000291