OXAZOLIDINONAS SUBSTITUIDAS Y SU USO

• Main Authors: PERNERSTORFER JOSEPH, LAMPE, THOMAS
• Format: Patent
• Language: Spanish
• Published: 13.06.2001
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

LA PRESENTE INVENCION SE REFIERE AL CAMPO DE LA COAGULACION SANGUINEA. EN ESPECIAL LA PRESENTE INVENCION SE REFIERE A NUEVOS DERIVADOSS DE OXAZOLIDINONA, A PROCEDIMIENTOS PARA SU PREPARACION ASI COMO A SU USO COMO PRINCIPIO ACTIVO EN MEDICAMENTOS. N-oxazolidinylmethyl-substituted (benzo)thiophene carboxamides (I) and their salts, hydrates and prodrugs are new. N-oxazolidinylmethyl-substituted (benzo)thiophene carboxamides of formula (I) and their salts, hydrates and prodrugs are new. [Image] R 1> : optionally benzo-fused thiophene, optionally substituted one or more times; R 2> : any selected organic group; R 3>-R 8> : same or different hydrogen or 1-6C alkyl. Excluded are compounds where R 2> = phenyl (optionally substituted once or more) and all of R 3>-R 8> are hydrogen. Independent claims are also included for the following: (1) preparation of (I); and (2) pharmaceutical composition containing (I), optionally also auxiliaries and carriers. ACTIVITY : Anticoagulant; cardiant; anti-anginal; vasotropic; thrombolytic; cerebroprotective; antiarthritic; antiarteriosclerotic; cytostatic; nootropic; neuroprotective. Test details are described but no results given. MECHANISM OF ACTION : Coagulation factor Xa Inhibitor.