METHODS AND COMPOSITIONS USEFUL IN GENERATING NON CANONICAL CD8+ T CELL RESPONSES
Methods of inducing a CD8+ T celi response to a heterologous antigen in which at least 10% of the CD8+ T cells areMHC-E restricted are disclosed. The method involves immunizing with a CMV vector that does not express UL128 and UL130 pro- teins. Also disclosed are recombinant CMV vectors comprising n...
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Main Authors | , , , , |
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Format | Patent |
Language | Chinese English |
Published |
12.07.2019
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Subjects | |
Online Access | Get full text |
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Summary: | Methods of inducing a CD8+ T celi response to a heterologous antigen in which at least 10% of the CD8+ T cells areMHC-E restricted are disclosed. The method involves immunizing with a CMV vector that does not express UL128 and UL130 pro- teins. Also disclosed are recombinant CMV vectors comprising nucleic acids encoding a heterologous protein antigen, a UL40 pro- tein, and a US28 protein but that do not express an active UL128 and UL130 protein. Also disclosed are recombinant CMV vectors comprising nucleic acids encoding a heterologous protein antigen, but that do not express an active UL40 protein, UL128 protein, UL130 protein, and optionally a US28 protein. Also disclosed are recombinant CMV vectors comprising nucleic acids encoding a heterologous protein antigen, but that do not express an active US28 protein, UL128 protein, UL130 protein, and optionally a UL40 protein. |
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Bibliography: | Application Number: HK20180113013 |