VACCINE AGAINST RSV

The present invention relates to compositions comprising a recombinant respiratory syncitial virus (RSV) Fusion (F) polypeptide that is stabilized in the pre-fusion conformation, wherein said RSV F polypeptide comprises at least one mutation as compared to a wild type RSV F polypeptide, wherein the...

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Bibliographic Details
Main Authors LANGEDIJK, Johannes, ROYMANS, Dirk, André, Emmy
Format Patent
LanguageChinese
English
Published 18.01.2019
Subjects
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Summary:The present invention relates to compositions comprising a recombinant respiratory syncitial virus (RSV) Fusion (F) polypeptide that is stabilized in the pre-fusion conformation, wherein said RSV F polypeptide comprises at least one mutation as compared to a wild type RSV F polypeptide, wherein the at least one mutation is selected from the group consisting of: a) a mutation of the amino acid aspartic acid (D) on position 486, b) a mutation of the amino acid aspartic acid (D) on position 489, and c) a mutation of the amino acid serine (S) on position 398 and/or the amino acid lysine (K) on position 394. The invention also relates to compositions comprising an isolated nucleic acid molecule encoding said stable RSV F polypeptides.
Bibliography:Application Number: HK20180110428