GENETICALLY MODIFIED MICE EXPRESSING CHIMERIC MAJOR HISTOCOMPATIBILITY COMPLEX (MHC) II MOLECULES

The invention provides genetically modified non-human animals that express a humanized MHC II protein (humanized MHC II α and β polypeptides), as well as embryos, cells, and tissues comprising the same. Also provided are constructs for making said genetically modified animals and methods of making t...

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Bibliographic Details
Main Authors MACDONALD, Lynn, MURPHY, Andrew, J, GURER, Cagan, STEVENS, Sean, VORONINA, Vera, TU, Naxin
Format Patent
LanguageChinese
English
Published 30.11.2018
Subjects
AGRICULTURE
ANIMAL HUSBANDRY
CARE OF BIRDS, FISHES, INSECTS
CHEMISTRY
FISHING
FORESTRY
HUMAN NECESSITIES
HUNTING
METALLURGY
NEW BREEDS OF ANIMALS
ORGANIC CHEMISTRY
PEPTIDES
REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR
TRAPPING
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Summary:The invention provides genetically modified non-human animals that express a humanized MHC II protein (humanized MHC II α and β polypeptides), as well as embryos, cells, and tissues comprising the same. Also provided are constructs for making said genetically modified animals and methods of making the same. Methods of using the genetically modified animals to study various aspects of human immune system are provided.
Bibliography:Application Number: HK20180109591