METHODS AND COMPOSITIONS FOR KILLING SENESCENT CELLS AND FOR TREATING SENESCENCE-ASSOCIATED DISEASES AND DISORDERS

Methods are provided herein for selectively killing senescent cells and for treating senescence-associated diseases and disorders by administering a senolytic agent. Senescence-associated diseases and disorders treatable by the methods using the senolytic agents described herein include cardiovascul...

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Main Authors DEMARIA, Marco, CHILDS, Bennett, G, JEON, Okhee, LABERGE, Remi-Martin, VASSEROT, Alain, Philippe, TCHKONIA, Tamar, VAN DEURSEN, Jan, M.A, ZHU, Yi, KIRKLAND, James, L, DAVALOS, Albert, ELISSEEFF, Jennifer, KIM, Chaekyu, DAVID, Nathaniel, CAMPISI, Judith, BAKER, Darren, J
Format Patent
LanguageChinese
English
Published 22.12.2017
Subjects
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:Methods are provided herein for selectively killing senescent cells and for treating senescence-associated diseases and disorders by administering a senolytic agent. Senescence-associated diseases and disorders treatable by the methods using the senolytic agents described herein include cardiovascular diseases and disorders associated with or caused by arteriosclerosis, such as atherosclerosis; idiopathic pulmonary fibrosis; chronic obstructive pulmonary disease; osteoarthritis; senescence-associated ophthalmic diseases and disorders; and senescence-associated dermatological diseases and disorders.
Bibliography:Application Number: HK20170105136