METHODS FOR TREATING OR PREDICTING RISK OF A VENTRICULAR TACHYARRHYTHMIA EVENT

Provided herein are methods for selecting a treatment for a subject that include (i) determining a level of soluble ST2 in a first biological sample from a subject obtained from the subject at a first time, (ii) determining a level of soluble ST2 in a second biological sample obtained from the subje...

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Bibliographic Details
Main Authors MEYER, TIMOTHY EDWARD, STOLEN, CRAIG MICHAEL, SNIDER, JAMES V, GERWIEN, ROBERT W
Format Patent
LanguageChinese
English
Published 11.03.2016
Subjects
CHEMISTRY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:Provided herein are methods for selecting a treatment for a subject that include (i) determining a level of soluble ST2 in a first biological sample from a subject obtained from the subject at a first time, (ii) determining a level of soluble ST2 in a second biological sample obtained from the subject at a second time point (iii) comparing the level of soluble ST2 in the first biological sample to the level of soluble ST2 in the second biological sample (iv) identifying a subject having an elevated level of soluble ST2 in the second biological sample compared to the level of soluble ST2 in the first biological sample as having an increased risk of a VTA (ventricular tachyarrhythmia) event and (v) selected an implanted cardiac defibrillator (ICD), a cardiac resynchronization therapy (CRT) device, or a combination ICD-CRT (CRT-D) device for the subject identified as having an increased risk of a VTA event. Also provided are methods for evaluating the risk of a VTA event in a subject.
Bibliography:Application Number: HK20150109315