CRYSTALLINE AND NON-CRYSTALLINE FORMS OF TOFACITINIB, AND A PHARMACEUTICAL COMPOSITION COMPRISING TOFACITINIB AND A PENETRATION ENHANCER

The present invention discloses novel crystalline and non-crystalline forms of 3-((3R,4R)-4-methyl-3-[methyl-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-amino]-pip-eridin-1-yl)-3-oxopropionitrile, pharmaceutical composition containing the same, preparations thereof and the uses thereof.

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Bibliographic Details
Main Authors JOHNSON, PHILLIP J. PJ, WHITE, TIMOTHY, D. TD, CHEKAL, BRIAN P. BP, MARGULIS, LEONID A. LA, FOTI, CHRISTOPHER JAMES CJ, MURPHY, BRENDAN J. BJ
Format Patent
LanguageChinese
English
Published 19.02.2016
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Summary:The present invention discloses novel crystalline and non-crystalline forms of 3-((3R,4R)-4-methyl-3-[methyl-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-amino]-pip-eridin-1-yl)-3-oxopropionitrile, pharmaceutical composition containing the same, preparations thereof and the uses thereof.
Bibliography:Application Number: HK20150108451