TRIAZOLOPYRIDINES

The present invention relates to triazolopyridine compounds of general formula (I) which are Monopolar Spindle 1 kinase (Mps-1 or TTK) inhibitors: in which R 1 , R 2 , R 3 , R 4 , and R 5 are as given in the description and in the claims, to methods of preparing said compounds, to pharmaceutical com...

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Bibliographic Details
Main Authors BRIEM, Hans H, SIEMEISTER, Gerhard G, PRECHTL, Stefan S, SCHULZE, Volker V, KOPPITZ, Marcus M, KOSEMUND, Dirk D, BOEMER, Ulf U, WENGNER, Antje, Margret AM, LIENAU, Philip P, SCHIROK, Hartmut H, HOLTON, Simon S, BADER, Benjamin B
Format Patent
LanguageChinese
English
Published 06.09.2013
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:The present invention relates to triazolopyridine compounds of general formula (I) which are Monopolar Spindle 1 kinase (Mps-1 or TTK) inhibitors: in which R 1 , R 2 , R 3 , R 4 , and R 5 are as given in the description and in the claims, to methods of preparing said compounds, to pharmaceutical compositions and combinations comprising said compounds, to the use of said compounds for manufacturing a pharmaceutical composition for the treatment or prophylaxis of proliferative diseases, as well as to intermediate compounds useful in the preparation of said compounds.
Bibliography:Application Number: HK20130105127