SULFONAMIDE DERIVATIVES AS BCL-2-SELECTIVE APOPTOSIS-INDUCING AGENTS FOR THE TREATMENT OF CANCER AND IMMUNE DISEASES BCL-2

Disclosed are compounds which inhibit the activity of anti-apoptotic Bcl-2 or Bcl-xL proteins, compositions containing the compounds and methods of treating diseases during which are expressed anti-apoptotic Bcl-2 protein.

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Main Authors HEXAMER, Laura, DOHERTY, George A, WANG, Le, McCLELLAN, William, J, SOUERS, Andrew, J, WENDT, Michael, D, DING, Hong, KUNZER, Aaron, PETROS, Andrew, M, PARK, Cheol-Min, TAO, Zhi-Fu, MANTEI, Robert, A, WANG, Gary, T, HANSEN, Todd, M, ELMORE, Steven, W, BRUNCKO, Milan, PARK, Chang, H, WANG, Xilu, HASVOLD, Lisa, SONG, Xiaohong, SULLIVAN, Gerard, M
Format Patent
LanguageChinese
English
Published 16.08.2013
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Abstract Disclosed are compounds which inhibit the activity of anti-apoptotic Bcl-2 or Bcl-xL proteins, compositions containing the compounds and methods of treating diseases during which are expressed anti-apoptotic Bcl-2 protein.
AbstractList Disclosed are compounds which inhibit the activity of anti-apoptotic Bcl-2 or Bcl-xL proteins, compositions containing the compounds and methods of treating diseases during which are expressed anti-apoptotic Bcl-2 protein.
Author HEXAMER, Laura
WANG, Le
DING, Hong
MANTEI, Robert, A
BRUNCKO, Milan
HASVOLD, Lisa
McCLELLAN, William, J
SOUERS, Andrew, J
PARK, Cheol-Min
ELMORE, Steven, W
TAO, Zhi-Fu
PETROS, Andrew, M
SONG, Xiaohong
WENDT, Michael, D
DOHERTY, George A
KUNZER, Aaron
SULLIVAN, Gerard, M
WANG, Xilu
WANG, Gary, T
PARK, Chang, H
HANSEN, Todd, M
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– fullname: WANG, Le
– fullname: McCLELLAN, William, J
– fullname: SOUERS, Andrew, J
– fullname: WENDT, Michael, D
– fullname: DING, Hong
– fullname: KUNZER, Aaron
– fullname: PETROS, Andrew, M
– fullname: PARK, Cheol-Min
– fullname: TAO, Zhi-Fu
– fullname: MANTEI, Robert, A
– fullname: WANG, Gary, T
– fullname: HANSEN, Todd, M
– fullname: ELMORE, Steven, W
– fullname: BRUNCKO, Milan
– fullname: PARK, Chang, H
– fullname: WANG, Xilu
– fullname: HASVOLD, Lisa
– fullname: SONG, Xiaohong
– fullname: SULLIVAN, Gerard, M
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Snippet Disclosed are compounds which inhibit the activity of anti-apoptotic Bcl-2 or Bcl-xL proteins, compositions containing the compounds and methods of treating...
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SubjectTerms CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
Title SULFONAMIDE DERIVATIVES AS BCL-2-SELECTIVE APOPTOSIS-INDUCING AGENTS FOR THE TREATMENT OF CANCER AND IMMUNE DISEASES BCL-2
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