SULFONAMIDE DERIVATIVES AS BCL-2-SELECTIVE APOPTOSIS-INDUCING AGENTS FOR THE TREATMENT OF CANCER AND IMMUNE DISEASES BCL-2

Disclosed are compounds which inhibit the activity of anti-apoptotic Bcl-2 or Bcl-xL proteins, compositions containing the compounds and methods of treating diseases during which are expressed anti-apoptotic Bcl-2 protein.

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Bibliographic Details
Main Authors HEXAMER, Laura, DOHERTY, George A, WANG, Le, McCLELLAN, William, J, SOUERS, Andrew, J, WENDT, Michael, D, DING, Hong, KUNZER, Aaron, PETROS, Andrew, M, PARK, Cheol-Min, TAO, Zhi-Fu, MANTEI, Robert, A, WANG, Gary, T, HANSEN, Todd, M, ELMORE, Steven, W, BRUNCKO, Milan, PARK, Chang, H, WANG, Xilu, HASVOLD, Lisa, SONG, Xiaohong, SULLIVAN, Gerard, M
Format Patent
LanguageChinese
English
Published 16.08.2013
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:Disclosed are compounds which inhibit the activity of anti-apoptotic Bcl-2 or Bcl-xL proteins, compositions containing the compounds and methods of treating diseases during which are expressed anti-apoptotic Bcl-2 protein.
Bibliography:Application Number: HK20130104083