VACCINE COMPOSITIONS BASED ON STICHOLYSIN ENCAPSULATED IN LIPOSOMES

The current invention relates to the field of Biotechnology applied to human health. Here it is described a vaccine vehicle wherein toxins from eukaryotic organisms are encapsulated into multilamellar vesicles obtained by the dehydration-rehydration procedure whose lipidic composition is dipalmitoyl...

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Main Authors MESA PARDILLO, CIRCE C, FERNANDEZ MOLINA, LUIS ENRIQUE LE, LANIO RUIZ, MARIA ELIANA ME, PAZOS SANTOS, ISABEL FABIOLA IF, VALLE GARAY, AISEL A, ALONSO BIOSCA, MARIA EUGENIA ME, LUZARDO LORENZO, MARIA DEL CARMEN MDC, LABORDE QUINTANA, RADY JUDITH RJ, CRUZ LEAL, YOELYS Y, TEJUCA MARTINEZ, MAYRA M, CANET SANTOS, LIEM L, ALVAREZ VALCARCEL, CARLOS MANUEL CM
Format Patent
LanguageChinese
English
Published 16.10.2015
Subjects
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Summary:The current invention relates to the field of Biotechnology applied to human health. Here it is described a vaccine vehicle wherein toxins from eukaryotic organisms are encapsulated into multilamellar vesicles obtained by the dehydration-rehydration procedure whose lipidic composition is dipalmitoylphosphatidylcholine: cholesterol in a 1:1 molar ratio for subcutaneous or intramuscular administration. These compositions do not require the use of other adjuvants. The disclosed compositions allow modulation of CTL-specific immune response against one or several antigens co-encapsulated into toxin-containing liposomes. The vaccinal vehicle of the present invention shows advantages over others disclosed by the previous art due to the robustness and functionality of the induced immune response as well as its immunomodulating properties.
Bibliography:Application Number: HK20130104046