ANTI-FERROPORTIN MONOCLONAL ANTIBODIES AND USES THEREOF

Provided are monoclonal antibodies and antigen-binding fragments thereof that bind to, and inhibit the activity of human FPN1, and which are effective in maintaining or increasing the transport of iron out of mammalian cells and/or maintaining or increasing the level of serum iron, reticulocyte coun...

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Bibliographic Details
Main Authors LEUNG, Donmienne, Doen, Mun, TANG, Ying, LUAN, Peng, WITCHER, Derrick, Ryan, MANETTA, Joseph, Vincent
Format Patent
LanguageChinese
English
Published 27.07.2012
Subjects
CHEMISTRY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Summary:Provided are monoclonal antibodies and antigen-binding fragments thereof that bind to, and inhibit the activity of human FPN1, and which are effective in maintaining or increasing the transport of iron out of mammalian cells and/or maintaining or increasing the level of serum iron, reticulocyte count, red blood cell count, hemoglobin, and/or hematocrit in a subject in vivo.
Bibliography:Application Number: HK20110113719