LOW HYGROSCOPIC ARIPIPRAZOLE DRUG SUBSTANCE AND PROCESSES FOR THE PREPARATION THEREOF

A pharmaceutical solid oral aripiprazole preparation is provided which has a) at least one dissolution rate measured after storage in the open at 25°C/60% RH for six months selected from the group consisting of 70 % or more at pH 4.5 after 60 minutes, and 55 % or more at pH 5.0 after 60 minutes; or...

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Main Authors KIYOSHI FUJIMOTO, TAKUJI BANDO, TSUYOSHI YABUUCHI, MAKOTO ISHIGAMI, NAOTO UTSUMI, JUNICHI KAWASAKI, MASANORI TAKAHASHI, SATOSHI AOKI, KAORU ABE, TSUTOMU FUJIMURA, MICHIAKI TOMINAGA, NORIYUKI KOBAYASHI, KOICHI SHINHAMA, YOSHIHIRO NISHIOKA, YOSHIHIRO OI, TOMONORI NAKAGAWA, SHOHEI YAMADA, KENJI TOMIKAWA, YOUICHI TANIGUCHI
Format Patent
LanguageEnglish
Published 16.07.2010
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PERFORMING OPERATIONS
PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SEPARATION
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
TRANSPORTING
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Summary:A pharmaceutical solid oral aripiprazole preparation is provided which has a) at least one dissolution rate measured after storage in the open at 25°C/60% RH for six months selected from the group consisting of 70 % or more at pH 4.5 after 60 minutes, and 55 % or more at pH 5.0 after 60 minutes; or b) at least one dissolution rate measured after storage in the open at 40°C/75% RH for 1 week selected from the group consisting of 70 % or more at pH 4.5 after 60 minutes, and 55 % or more at pH 5.0 after 60 minutes.
Bibliography:Application Number: HK20100100649