RECOMBINANT INTERFERON

The present invention provides IFN±2 mutants and active fragments, analogs, derivatives, and variants thereof that have improved specific agonist or antagonist activity as compared to wild-type IFN±2. The present invention further provides pharmaceutical compositions comprising IFN±2 mutants useful...

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Bibliographic Details
Main Authors DIEGO JAITIN, EYAL KALIE, LAILA C. ROISMAN, GIDEON SCHREIBER
Format Patent
LanguageEnglish
Published 25.04.2014
Subjects
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Summary:The present invention provides IFN±2 mutants and active fragments, analogs, derivatives, and variants thereof that have improved specific agonist or antagonist activity as compared to wild-type IFN±2. The present invention further provides pharmaceutical compositions comprising IFN±2 mutants useful for treating or preventing cancer, autoimmune diseases, infectious diseases or disorders associated with increased expression of IFN±2.
Bibliography:Application Number: HK20090104314