METHOD FOR DETERMINING THE AMOUNT OF CONJUGATED TAXANE IN POLYGLUTAMIC ACID-TAXANE CONJUGATES

The invention relates to a method for determining the amount of conjugated taxane, in particular paclitaxel, in a PGA-taxane conjugate said method comprising: a) reacting the PGA-taxane conjugate with a compound formula (I): €ƒ€ƒ€ƒ€ƒ€ƒ€ƒ€ƒ€ƒ R 1 R 2 N-NH 2 €ƒ€ƒ€ƒ€ƒ€ƒ(I) wherein R 1 and R 2 are as de...

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Bibliographic Details
Main Authors FAZIONI, STEFANO, HOVDA, KEITH, SIVIERO, LUIGI, SPOONEMORE, HOLLY, LIVI, VALERIA, MCKENNON, MARC
Format Patent
LanguageEnglish
Published 27.02.2009
Subjects
INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES
MEASURING
PHYSICS
TESTING
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Summary:The invention relates to a method for determining the amount of conjugated taxane, in particular paclitaxel, in a PGA-taxane conjugate said method comprising: a) reacting the PGA-taxane conjugate with a compound formula (I): €ƒ€ƒ€ƒ€ƒ€ƒ€ƒ€ƒ€ƒ R 1 R 2 N-NH 2 €ƒ€ƒ€ƒ€ƒ€ƒ(I) wherein R 1 and R 2 are as defined in the description; to give a unbound taxane and a PGA hydrazide and b) determining the amount of unbound taxane.
Bibliography:Application Number: HK20080113121