USE OF CARBON-2-MODIFIED-19-NOR-VITAMIN D ANALOGS IN THE MANUFACTURE OF A MEDICAMENT FOR INDUCING THE FORMATION OF NEW BONE

• Main Authors: NIRUPAMA K. SHEVDE, HECTOR F. DELUCA, J. WESLEY PIKE
• Format: Patent
• Language: English
• Published: 21.04.2006
• Subjects: APPARATUS OR METHODS FOR ORAL OR DENTAL HYGIENE; BANDAGES, DRESSINGS OR ABSORBENT PADS; DENTISTRY; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF,TUBULAR STRUCTURES OF THE BODY, E.G. STENTS; FILTERS IMPLANTABLE INTO BLOOD VESSELS; FIRST-AID KITS; FOMENTATION; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; PROSTHESES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS; TREATMENT OR PROTECTION OF EYES OR EARS

It has been discovered that the 2-carbon-modified derivatives of 1α,25-dihydroxyvitamin D3 specifically stimulate osteoblasts to form new bone. The ability of the 2-carbon-modified vitamin D analogs to stimulate new bone formation suggest that these compounds can be used where synthesis of new bone...