USE OF CARBON-2-MODIFIED-19-NOR-VITAMIN D ANALOGS IN THE MANUFACTURE OF A MEDICAMENT FOR INDUCING THE FORMATION OF NEW BONE

• Main Authors: NIRUPAMA K. SHEVDE, HECTOR F. DELUCA, J. WESLEY PIKE
• Format: Patent
• Language: English
• Published: 21.04.2006
• Subjects: APPARATUS OR METHODS FOR ORAL OR DENTAL HYGIENE; BANDAGES, DRESSINGS OR ABSORBENT PADS; DENTISTRY; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF,TUBULAR STRUCTURES OF THE BODY, E.G. STENTS; FILTERS IMPLANTABLE INTO BLOOD VESSELS; FIRST-AID KITS; FOMENTATION; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; PROSTHESES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS; TREATMENT OR PROTECTION OF EYES OR EARS

It has been discovered that the 2-carbon-modified derivatives of 1α,25-dihydroxyvitamin D3 specifically stimulate osteoblasts to form new bone. The ability of the 2-carbon-modified vitamin D analogs to stimulate new bone formation suggest that these compounds can be used where synthesis of new bone is required. Thus, these compounds can be used either systemically or locally to stimulate the growth of bone transplants, to increase the rate of fracture healing and thereby reduce the time required for the healing of fractures, the stimulation of bone growth when required for replacement surgery, and also for the growth of bone to implants or other devices required to maintain the skeleton or teeth in the proper positions.