METHOD FOR THE PREPARATION OF ESCITALOPRAM

A novel method is provided for the manufacture of escitalopram. The method comprises chromatographic separation of the enantiomers of citalopram or an intermediate in the production of citalopram using a chiral stationary phase such as Chiralpak™ AD or Chiralcel™ OD. Novel chiral intermediates for t...

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Main Authors COX, GEOFFEY, GEISER, FIONA, ASSENZA, SEBASTIAN, P, BECH SOMMER, MICHAEL, AHMADIAN, HALEH, LEE, JAMES, NIELSEN, OLE, NAIR, USHA, BROESEN, PETER, DAPREMONT, OLIVIER, HARIHARAN, SHANKAR, PETERSEN, HANS, SUTEU, CHRISTINA, PEDERSEN, HENRIK
Format Patent
LanguageEnglish
Published 20.05.2005
Subjects
ACYCLIC OR CARBOCYCLIC COMPOUNDS
APPARATUS THEREFOR
CHEMISTRY
GENERAL METHODS OF ORGANIC CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:A novel method is provided for the manufacture of escitalopram. The method comprises chromatographic separation of the enantiomers of citalopram or an intermediate in the production of citalopram using a chiral stationary phase such as Chiralpak™ AD or Chiralcel™ OD. Novel chiral intermediates for the synthesis of Escitalopram made by said method are also provided.
Bibliography:Application Number: HK20050101842