USE OF BIODEGRADABLE MICROSPHERES WHICH RELEASE AN ANTICANCER AGENT, FOR TREATING GLIOBLASMA

The use of biodegradable microspheres that liberate a radiosensitive anticancer agent at the site of surgery to remove glioblastoma, these being used in conjunction with radiotherapy, is new. The use of biodegradable microspheres that liberate a radiosensitive anticancer agent at the site of surgery...

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Bibliographic Details
Main Authors JEAN-PIERRE BENOIT, NATHALIE FAISANT, PHILIPPE MENEI
Format Patent
LanguageChinese
English
Published 23.12.2005
Subjects
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:The use of biodegradable microspheres that liberate a radiosensitive anticancer agent at the site of surgery to remove glioblastoma, these being used in conjunction with radiotherapy, is new. The use of biodegradable microspheres that liberate a radiosensitive anticancer agent at the site of surgery to remove glioblastoma, these being used in conjunction with radiotherapy. The microspheres containing the anticancer agent are coated with a polymer that delays and prolongs the liberation of the active material, and are inserted into the area of the excision at least every square cm to a depth of 2 - 3 cm so as to maintain a therapeutically-effective concentration in the parenchymal space whilst radiotherapy is carried out, increasing the patient's survival time by at least 90 weeks. The microspheres are administered in a suspension containing 1 - 1.5 % (weight/volume) of a viscous agent, 0.5 - 1.5 % of a surfactant, and 3.5 - 4.5 % of an isotonic agent.
Bibliography:Application Number: HK20020108661