Chemokine receptor binding heterocyclic compounds

Heterocyclic compounds that bind chemokine receptors and inhibit the binding of their natural ligands are disclosed. The invention compounds are protective against infection by HIV and exert effects characteristic of antagonists to the CXCR4 receptor.

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Bibliographic Details
Main Authors YUANXI ZHOU, DOMINIQUE SCHOLS, RANATO SKERLJ, SIQIAO NAN, MCEACHERN, ERNES, J, CURTIS HARWIG, GARY BRIDGER, AL KALLER, DAVID BOGUCKI, WILSON, TREVOR, R, JASON CRAWFORD, BEM ATSMA
Format Patent
LanguageEnglish
Published 04.10.2002
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:Heterocyclic compounds that bind chemokine receptors and inhibit the binding of their natural ligands are disclosed. The invention compounds are protective against infection by HIV and exert effects characteristic of antagonists to the CXCR4 receptor.
Bibliography:Application Number: HK20020103690