TRICYCLIC INHIBITORS OF POLY(ADP-RIBOSE) POLYMERASES

Compounds of the formula below are poly(ADP-ribosyl)transferase (PARP) inhibitors, and are useful as therapeutics in treatment of cancers and the amelioration of the effects of stroke, head trauma, and neurodegenerative disease. As cancer therapeutics, the compounds of the invention may be used, e.g...

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Bibliographic Details
Main Authors STEPHEN EVAN WEBBER, JAYASHREE TIKHE, STACIE S. CANAN-KOCH, LARS HENRIK THORESEN
Format Patent
LanguageEnglish
Published 28.06.2002
Edition7
Subjects
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Summary:Compounds of the formula below are poly(ADP-ribosyl)transferase (PARP) inhibitors, and are useful as therapeutics in treatment of cancers and the amelioration of the effects of stroke, head trauma, and neurodegenerative disease. As cancer therapeutics, the compounds of the invention may be used, e.g., in combination with cytotoxic agents and/or radiation.
Bibliography:Application Number: HK20020102476