Tricyclic triazolobenzazepine derivatives, processfor producing the same, and antiallergic

• Main Authors: MAKI SHIOBARA, TOYOAKI ISHIKURA, TOSHIO NISHIZUKA, KENICHI FUSHIHARA, HIDEO KITAGAWA, HIROMI TAKATA, SACHIKO MIYAMOTO, YASUO OHTSUKA, MAMI KAWAGUCHI, TAKASHI SHISHIKURA, YUMIKO OKADA, SOHJIRO SHIOKAWA, SEIJI TSUTSUMI
• Format: Patent
• Language: English
• Published: 30.08.2002
• Edition: 7
• Subjects: ACYCLIC OR CARBOCYCLIC COMPOUNDS; ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM; CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

Tricyclic triazolobenzazepine derivatives in the form of a prodrug are provided. The compounds according to the present invention are those represented by formula (I) and pharmacologically acceptable salts and solvates thereof. The compounds are useful as antiallergic agents and exhibit excellent bioavailability. wherein R represents hydrogen, OH, alkyl or phenyl alkyl, R , R , R , and R represent hydrogen, halogen, optionally protected hydroxyl, formyl, optionally substituted alkyl, alkenyl, alkoxy or the like, and Q represents a group selected from the following groups (i) to (iv), halogen, or alkoxy: