Tricyclic triazolobenzazepine derivatives, processfor producing the same, and antiallergic

Tricyclic triazolobenzazepine derivatives in the form of a prodrug are provided. The compounds according to the present invention are those represented by formula (I) and pharmacologically acceptable salts and solvates thereof. The compounds are useful as antiallergic agents and exhibit excellent bi...

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Main Authors MAKI SHIOBARA, TOYOAKI ISHIKURA, TOSHIO NISHIZUKA, KENICHI FUSHIHARA, HIDEO KITAGAWA, HIROMI TAKATA, SACHIKO MIYAMOTO, YASUO OHTSUKA, MAMI KAWAGUCHI, TAKASHI SHISHIKURA, YUMIKO OKADA, SOHJIRO SHIOKAWA, SEIJI TSUTSUMI
Format Patent
LanguageEnglish
Published 30.08.2002
Edition7
Subjects
ACYCLIC OR CARBOCYCLIC COMPOUNDS
ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:Tricyclic triazolobenzazepine derivatives in the form of a prodrug are provided. The compounds according to the present invention are those represented by formula (I) and pharmacologically acceptable salts and solvates thereof. The compounds are useful as antiallergic agents and exhibit excellent bioavailability. wherein R represents hydrogen, OH, alkyl or phenyl alkyl, R , R , R , and R represent hydrogen, halogen, optionally protected hydroxyl, formyl, optionally substituted alkyl, alkenyl, alkoxy or the like, and Q represents a group selected from the following groups (i) to (iv), halogen, or alkoxy:
Bibliography:Application Number: HK20010103502