Cannabinol-11-oic acid derivatives useful as antiinflammatory agents and analgesics

The present invention relates to non-psychoactive derivatives of tetrahydro-cannabinol, which exhibit anti-inflammatory, analgesic and leukocyte antiadhesion activities. The invention includes novel derivatives of (3R,4R)-DELTA8-tetrahydrocannabinol-11-oic acids [hereinafter referred to as (3R,4R)-D...

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Bibliographic Details
Main Author BURNSTEIN, SUMNER, H
Format Patent
LanguageEnglish
Published 20.04.2001
Edition7
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:The present invention relates to non-psychoactive derivatives of tetrahydro-cannabinol, which exhibit anti-inflammatory, analgesic and leukocyte antiadhesion activities. The invention includes novel derivatives of (3R,4R)-DELTA8-tetrahydrocannabinol-11-oic acids [hereinafter referred to as (3R,4R)-DELTA8-THC-11-oic acid], as well as pharmaceutical compositions containing the (3R,4R)-DELTA8-THC-11-oic acid derivatives. The invention further covers methods of administering the novel derivatives and pharmaceutical compositions as therapeutic agents in the treatment of pain and tissue inflammation. Non-psychoactive derivatives of DELTA8-THC-11-oic acid are described which have analgesic and anti-inflammatory properties.
Bibliography:Application Number: HK20010100725