Neurotrophin-3 a novel neurotrophic factor related to nerve growth factor and brain derived neurotrophic factor

• Main Authors: PETER C. MAISONPIERRE, ANDREAS HOHN, YVES-ALAIN BARDE, KAREN BAILEY, RONALD M. LINDSAY, GEORGE YANCOPOULOS, HANS F. E. THOENEN, MARK E. FURTH, JOACHIM LEIBROCK
• Format: Patent
• Language: English
• Published: 05.03.1999
• Edition: 6
• Subjects: BEER; BIOCHEMISTRY; BLASTING; CHEMISTRY; COMBUSTION ENGINES; COMBUSTION ENGINES IN GENERAL; COMPOSITIONS OR TEST PAPERS THEREFOR; COMPOSITIONS THEREOF; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES; CULTURE MEDIA; DERIVATIVES THEREOF; ENZYMOLOGY; FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE; HEATING; HOT-GAS OR COMBUSTION-PRODUCT ENGINE PLANTS; HUMAN NECESSITIES; HYGIENE; INTERNAL-COMBUSTION PISTON ENGINES; LIGHTING; MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS; MECHANICAL ENGINEERING; MEDICAL OR VETERINARY SCIENCE; METALLURGY; MICROBIOLOGY; MICROORGANISMS OR ENZYMES; MUTATION OR GENETIC ENGINEERING; NUCLEIC ACIDS; NUCLEOSIDES; NUCLEOTIDES; ORGANIC CHEMISTRY; PEPTIDES; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; PROCESSES OF PREPARING SUCH COMPOSITIONS; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS; SPIRITS; SUGARS; VINEGAR; WEAPONS; WINE

NT3 is a member of the DBNF gp. It is based in part on the identification of regions of nucleic acid sequence homology shared by BDNF and NGF. The regions of homology may be used to identify new members of the BDNF/NGF gene gp. See US application No. 400,591 filed 30 August, 1989. The purified NT-3 protein and its prodn. by growing a host cell comprising the DNA molecule are claimed. The protein may be glycosylated or unglycosylated. Antibodies to NT-3 are also claimed and are produced by immunising a host animal with a neurotrophin-3 protein or its fragment.